Pacemaker Channels Produce an Instantaneous Current
نویسندگان
چکیده
منابع مشابه
Pacemaker channels produce an instantaneous current.
Spontaneous rhythmic activity in mammalian heart and brain depends on pacemaker currents (I(h)), which are produced by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here, we report that the mouse HCN2 pacemaker channel isoform also produced a large instantaneous current (I(inst(HCN2))) in addition to the well characterized, slowly activating I(h). I(inst(HCN2)) was specifi...
متن کاملDistinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents
Hyperpolarization-activated HCN pacemaker channels are critical for the generation of spontaneous activity and the regulation of excitability in the heart and in many types of neurons. These channels produce both a voltage-dependent current (I(h)) and a voltage-independent current (I(inst) or VIC). In this study, we explored the molecular basis of the voltage-independent current. We found that ...
متن کاملCurrent pacemaker and defibrillator therapy.
BACKGROUND Pacemakers have been available for 50 years, and implantable cardiac defibrillators for 25. Clear indications for each have been established on the basis of data from randomized clinical trials (RCTs). METHODS This review article is the product of a collaborative effort by a cardiologist and a cardiac surgeon. The authors arrived at a consensus through a selective review of the lit...
متن کاملO23: Modulation of Pacemaker Channels and Rhythmic Thalamic Activity by Demyelination and Inflammatory Cytokines
The thalamus is a central element for the generation of rhythmic oscillatory activity under physiological and pathophysiological conditions. Especially slow oscillations in the delta and theta frequency band which normally occur during slow-wave sleep are associated with a number of neuropsychiatric conditions if they occur during wakefulness and may be the basis for the generation of character...
متن کاملHyperpolarization-Activated ‘Pacemaker Current’ — A Funny Current in Models of SA Nodal Pacemaker Cells
A typical feature of sinoatrial (SA) nodal pacemaker cells is the presence of an ionic current that activates upon hyperpolarization. The contribution of this hyperpolarization-activated current, If, which is also known as the ‘funny current’ or ‘pacemaker current’, to the spontaneous pacemaker activity of SA nodal cells remains a matter of intense debate. We used experimentally recorded action...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m106974200